Nanomedicine: photo - activated nanostructured titanium dioxide as a promising anticancer agent

N. Lagopati, K. Evangelou, P. Falaras, E.-Ph.C.Tsilibary, P. V.S.Vasileiou, S. Havaki, A. Angelopoulou, E.A. Pavlatou, V.G.Gorgoulis

Pharmacology & Therapeutics (2021), 222, 107795

The multivariate condition of cancer disease has been approached in various ways, by the scientific community. Recent studies focus on individualized treatments, minimizing the undesirable consequences of the conventional methods, but the development of an alternative effective therapeutic scheme remains to be held. Nanomedicine could provide a solution, filling this gap, exploiting the unique properties of innovative nanostructured materials. Nanostructured titanium dioxide (TiO2) has a variety of applications of daily routine and of advanced technology. Due to its biocompatibility, it has also a great number of biomedical applications. It is now clear that photo-excited TiO2 nanoparticles, induce generation of pairs of electrons and holes which react with water and oxygen to yield reactive oxygen species (ROS) that have been proven to damage cancer cells, triggering controlled cellular processes. The aim of this review is to provide insights into the field of nanomedicine and particularly into the wide context of TiO2-NP-mediated anticancer effect, shedding light on the achievements of nanotechnology and proposing this nanostructured material as a promising anticancer photosensitizer.

doi: 10.1016/j.pharmthera.2020.107795

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